Vilon

Vilon (Oral)

Vilon is a synthetic dipeptide (Lys-Glu) studied in the peptide bioregulator literature as a thymus-related immunomodulatory bioregulator. It is discussed for immune homeostasis and age-associated immune changes, though high-quality randomized evidence is limited.

Dosing Protocols

Reconstitute: Add 3.0 mL bacteriostatic water → ~6.67 mg/mL concentration.
Typical range: 67–670 mcg once daily for 5 consecutive days per cycle.
Easy measuring: At 6.67 mg/mL, 1 unit = 0.01 mL ≈ 66.7 mcg on a U-100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C; reconstituted: refrigerate at 2–8 °C, use within 1 week.

Schedule: 5 consecutive days of subcutaneous injections per 4-week cycle; repeat for 2–4 cycles.
Cycle Length: 5 days on, ~23 days off (4-week cycle); run 2–4 cycles.
Goal: Support immune modulation and thymic function markers based on preclinical observations.

Phase	Dose	Syringe (U-100)
Cycle 1, Day 1	67 mcg	1 unit (0.01 mL)
Cycle 1, Day 2	133 mcg	2 units (0.02 mL)
Cycle 1, Day 3	200 mcg	3 units (0.03 mL)
Cycle 1, Day 4	267 mcg	4 units (0.04 mL)
Cycle 1, Day 5	333 mcg	5 units (0.05 mL)
Cycle 2+ (Days 1–5)	333–667 mcg	5–10 units (0.05–0.10 mL)

Benefits

• Studied for normalization of immune parameters in aging models
• May support T-cell maturation and immune balance (limited evidence)
• Investigated for reduced frequency/severity of respiratory infections in observational settings
• Potential support of vaccine responsiveness in older adults (hypothesized)
• May modulate inflammatory cytokine balance (preclinical)

Mechanism of Action

Proposed to influence gene expression programs in immune cells (especially thymus-related pathways) and normalize immune cell differentiation and cytokine output. Effects are described as immunorestorative, potentially improving T-cell function and balancing pro/anti-inflammatory signaling.

Side Effects

• Generally well tolerated in reported uses
• Headache
• GI upset
• Allergic reaction (rare)

Side Effect Management

• Start low; take with food if GI upset
• Discontinue if rash/swelling occurs

Contraindications

• Pregnancy/breastfeeding
• Known hypersensitivity
• Autoimmune disease—use caution due to immune modulation
• Transplant recipients on immunosuppression

Research Citations

PubMed/DOI-linked citations for verification. Many studies are preclinical (animal/in-vitro) or early clinical.

1. Khavinson VKh. Peptide bioregulators and immune aging (review/overview). DOI Link
2. Ashmarin IP, Khavinson V. Regulatory peptides: mechanisms (review). DOI Link
3. Immunomodulatory effects of thymic peptides in aging (review context). DOI Link

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