Gut Health
Peptides researched for GI protection, gut lining repair, inflammation reduction, and microbiome support. Each compound below links to its full dosing protocol.
Research Use Only. All dosing information is for educational purposes. Consult a licensed healthcare provider before making health decisions.
BPC-157
Body Protection Compound-157 — one of the most studied peptides for gut healing. Found naturally in human stomach juices, it stimulates angiogenesis, accelerates wound healing, and has potent anti-inflammatory and antioxidant properties.
Route: Subcutaneous injection
Reconstitution: 3.0 mL bacteriostatic water → 1.67 mg/mL
Dose Range: 200–600 mcg once daily (titrate up)
Cycle: 8–12 weeks (up to 16 weeks)
Schedule: Weeks 1–2: 200 mcg → Weeks 3–4: 400 mcg → Weeks 5–8+: 600 mcg
- Stable Gastric Pentadecapeptide BPC 157 and Wound Healing — Front Pharmacol, 2021
- BPC 157 and Standard Angiogenic Growth Factors: GI Tract Healing — Curr Pharm Des, 2018
- BPC 157 and Intestinal Anastomoses Therapy in Rats — A Review — Pharmaceuticals, 2024
KPV
A tripeptide (Lys-Pro-Val) derived from α-MSH with strong anti-inflammatory and immunomodulatory effects, particularly researched for gastrointestinal and dermatologic inflammatory conditions. Exerts anti-inflammatory effects without pigmentation activity.
Route: Subcutaneous injection or Oral
Reconstitution: 3.0 mL bacteriostatic water → 3.33 mg/mL
Dose Range: 200–500 mcg once daily (titrate up)
Cycle: 8–12 weeks (up to 16 weeks)
Schedule: Week 1: 200 mcg → Week 2: 300 mcg → Week 3: 400 mcg → Weeks 4–8: 500 mcg
- Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of IBD — Inflamm Bowel Dis, 2008
- PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation — Gastroenterology, 2008
- Orally Targeted Delivery of KPV Efficiently Alleviates Ulcerative Colitis — Mol Ther, 2017
LL-37
A human cathelicidin antimicrobial peptide with broad antimicrobial activity. Researched for anti-biofilm effects, immune modulation, and wound healing in the gut lining. Modulates innate immunity and inflammation.
Route: Subcutaneous injection
Reconstitution: 3.0 mL bacteriostatic water → 1.67 mg/mL
Dose Range: 100–400 mcg once daily (gradual titration)
Cycle: 8–12 weeks (up to 16 weeks)
Schedule: Week 1: 50 mcg → Week 2: 100 mcg → Week 3: 150 mcg → Week 4: 200 mcg → Weeks 6–8: 300–400 mcg
- Cathelicidin LL-37 preserves intestinal barrier and organ function — Biomed Pharmacother, 2023
- Anti-microbial peptide functionalized vesicles alleviate ulcerative colitis in mice — J Extracell Vesicles, 2024
Glutathione
The body’s most abundant endogenous antioxidant. Injectable glutathione bypasses GI degradation and supports oxidative stress defense, detoxification, and immune function — all critical for gut barrier integrity and repair.
Route: Subcutaneous injection
Reconstitution: 2.0 mL bacteriostatic water → 300 mg/mL
Dose Range: 100–200 mg once daily (titrate up)
Cycle: 4–8 weeks (2–4 weeks off between cycles)
Schedule: Weeks 1–2: 100 mg → Weeks 3–4: 150 mg → Weeks 5–8: 200 mg
- Glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation — Cell Metab, 2024
- Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review — Intern Emerg Med, 2024
Thymosin Alpha-1 (TA1)
A 28-amino-acid immune-modulating peptide that enhances host defense mechanisms. Researched for chronic infections and as an immune adjuvant — supports gut immune function and intestinal barrier defense.
Route: Subcutaneous injection
Reconstitution: 3.0 mL bacteriostatic water → 1.67 mg/mL
Dose Range: 300–500 mcg once daily (titrate up)
Cycle: 8–12 weeks (up to 16 weeks)
Schedule: Week 1: 300 mcg → Weeks 2–8: 500 mcg
- Thymosin alpha-1 — Comprehensive Review — Am J Health Syst Pharm, 2001
- Efficacy and safety of thymosin α1 for sepsis (TESTS): phase 3 trial — BMJ, 2025
- Thymosin alpha-1 treatment in chronic hepatitis B — Expert Opin Biol Ther, 2015
All information is intended strictly for educational and research purposes. Not medical advice. Consult a licensed healthcare provider before making any health decisions.