Hormonal imbalance spans low testosterone, estrogen dominance, thyroid dysfunction, adrenal fatigue, and GH deficiency — all involving dysregulation of the neuroendocrine axes (HPG, HPA, HPT) that govern systemic hormonal output. Peptide research targets these axes upstream, stimulating endogenous hormone production rather than replacing it exogenously.
1. Ipamorelin + CJC-1295 — GH/IGF-1 Axis Restoration
Age-related GH decline (somatopause) is one of the most impactful hormonal shifts in adults. Ipamorelin/CJC restores physiological GH pulsatility, which downstream normalizes IGF-1, improves body composition, supports bone density, and contributes to testosterone and thyroid optimization through improved metabolic status.
Dosing Protocol: 200–300 mcg Ipamorelin + 100–200 mcg CJC-1295 SubQ before bed. 5 on/2 off. Cycle: 12–16 weeks.
2. Kisspeptin — HPG Axis / Sex Hormone Regulation
Kisspeptin is the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis — it controls GnRH pulsatility, LH and FSH release, and downstream sex hormone production. In both men and women with central hypogonadism or suppressed hormonal output, kisspeptin directly restores the hypothalamic drive for sex hormone production.
Dosing Protocol: 50–100 mcg SubQ 2–3x weekly. Clinical research uses 0.3–10 nmol/kg; 50–100 mcg SubQ extrapolates from published data.
3. Epithalon — Pineal / Circadian Hormone Regulation
The pineal gland regulates melatonin, cortisol, and thyroid hormone circadian rhythms. Age-related pineal calcification disrupts these rhythms, contributing to hormonal dysregulation across multiple axes. Epithalon restores pineal function, normalizes melatonin and cortisol diurnal patterns, and has demonstrated improvements in thyroid and GH hormone profiles in aging subjects.
Dosing Protocol: 5–10 mg SubQ daily for 10-day courses. Repeat 2x per year.
4. Sermorelin — GHRH Axis Support
Sermorelin is a GHRH analog that stimulates pituitary GH release through the natural GHRH receptor, preserving the physiological pulsatility and feedback mechanisms. It provides a gentler GH axis stimulation than GHRP/GHRH combinations and is often used for long-term GH axis support in hormonal optimization protocols.
Dosing Protocol: 200–300 mcg SubQ before bed. 5 on/2 off. Can be used as a lower-intensity alternative to Ipamorelin/CJC or rotated in long-term protocols.
Ipamorelin/CJC restores the GH/IGF-1 axis — the most impactful hormonal decline in aging adults. Kisspeptin directly stimulates the HPG axis governing sex hormone production without exogenous hormone introduction. Epithalon normalizes the pineal circadian hormone regulation that orchestrates all other hormonal rhythms. Sermorelin provides sustained GHRH support for the pituitary.
Research Use Only. All information on this page is for educational purposes only and is not medical advice. PepSherpa does not sell peptides. Consult a licensed healthcare provider before making any health decisions. Many of the studies cited are preclinical (animal/in-vitro).