Selank

Selank

Research use only. Not approved as a drug in many jurisdictions. This page is educational and not medical advice.

Description

Selank is a synthetic heptapeptide developed in Russia and described as an analog of tuftsin (a natural immunomodulatory peptide fragment of IgG). It has been studied for anxiolytic and nootropic-like effects, with proposed actions involving GABAergic balance, neurotrophic signaling, and immune modulation. In research and anecdotal use, it is commonly administered intranasally; subcutaneous administration is also discussed in peptide communities.

Why it’s notable: Selank is often positioned as an anxiolytic that may have fewer sedating effects than benzodiazepines (research context; not a substitute for medical care).

Potential Benefits (as studied)

  • Anxiolytic-like effects in clinical/research reports (notably Russian literature).
  • Possible cognitive support under stress (memory/attention measures in some studies).
  • Potential modulation of inflammatory/immune markers (tuftsin-analog rationale).
  • May influence expression of certain neurotrophic factors in experimental models.

Side Effects

  • Nasal irritation (intranasal use).
  • Headache (occasionally reported).
  • Transient fatigue or agitation (individual variability).
  • Allergic-type reactions are possible with any peptide (rare; discontinue and seek care).

Contraindications / Who Should Avoid

  • Pregnancy/breastfeeding (avoid; insufficient safety data).
  • Severe psychiatric illness without clinician oversight.
  • Known hypersensitivity to peptide components/excipients.
  • Autoimmune disease or immunomodulator use: discuss with a clinician.

Dosing Protocols (Research/Reference)

Intranasal (common reference range)

  • 250–500 mcg per dose, 2–3× daily.
  • Typical course discussions: 10–14 days, then break (varies by protocol).

Subcutaneous (less common)

  • 250–500 mcg per dose, 1–2× daily (community reference; not standardized).

Reconstitution (lyophilized vial reference)

  • Reconstitute with bacteriostatic water using sterile technique.
  • Example: add 2 mL to a 10 mg vial → 5 mg/mL.
  • At 5 mg/mL, a 500 mcg dose = 0.10 mL (10 IU on a U-100 syringe).
Tip: Intranasal dosing depends on spray bottle calibration (mcg per spray). Without calibration, dosing is guesswork.

Stacking Suggestions (Research Context)

  • Often discussed alongside Semax for “daytime focus + calm” protocols; start one at a time to assess tolerance.
  • May be paired with sleep/stress interventions (CBT, breathwork, magnesium) as foundational support.

Research Sources (PubMed)

  1. Ashmarin IP, Nezavibatko VN, et al. Neurosci Behav Physiol. 2003. PMID: 12680677
  2. Kozlovskii II et al. Neurosci Behav Physiol. 2008. PMID: 18320176
  3. Morozov SG, et al. Bull Exp Biol Med. 2003. PMID: 14731267
  4. Andreeva LA et al. Bull Exp Biol Med. 2006. PMID: 17172861
  5. Gudasheva TA, et al. Neurosci Behav Physiol. 2008. PMID: 18991527
  6. Kost NV, et al. Bull Exp Biol Med. 2009. PMID: 20108520
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