IMPORTANT: Read the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.
BPC (Body Protection Compound)-157 is a naturally occurring peptide found in human stomach juices that works by stimulating angiogenesis (the formation of new blood vessels). It accelerates the wound-healing process through multiple mechanisms; is a potent anti-inflammatory; and has antioxidant benefits. Well tolerated by most, this is one of the most popular peptides in the industry for its usefulness in treating a broad spectrum of injuries and ailments.
— 5 mg Vial —
Reconstitute: Add 3.0 mL bacteriostatic water → 1.67 mg/mL concentration.
Typical daily range: 200–600 mcg once daily (gradual titration).
Easy measuring: At 1.67 mg/mL, 1 unit = 0.01 mL ≈ 16.7 mcg on a U-100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C; reconstituted: refrigerate at 2–8 °C, avoid freeze-thaw cycles.
Schedule: Daily subcutaneous injections for 8–12 weeks (extend to 16 weeks if desired).
Cycle Length: 8–12 weeks; optional extension to 16 weeks.
Goal: Support tissue-healing and recovery processes based on preclinical evidence.
Frequency: Inject once daily subcutaneously.
| Phase | Dose | Syringe (U-100) |
|---|---|---|
| Weeks 1–2 | 200 mcg (0.2 mg) | 12 units (0.12 mL) |
| Weeks 3–4 | 400 mcg (0.4 mg) | 24 units (0.24 mL) |
| Weeks 5–8+ | 600 mcg (0.6 mg) | 36 units (0.36 mL) |
— 10 mg Vial —
Reconstitute: Add 3.0 mL bacteriostatic water → 3.33 mg/mL concentration.
Typical daily range: 200–600 mcg once daily (gradual titration).
Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U-100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C; reconstituted: refrigerate at 2–8 °C, avoid freeze-thaw cycles.
Schedule: Daily subcutaneous injections for 8–12 weeks (extend to 16 weeks if desired).
Cycle Length: 8–12 weeks; optional extension to 16 weeks.
Goal: Support tissue-healing and recovery processes based on preclinical evidence.
Frequency: Inject once daily subcutaneously.
| Phase | Dose | Syringe (U-100) |
|---|---|---|
| Weeks 1–2 | 200 mcg (0.2 mg) | 6 units (0.06 mL) |
| Weeks 3–4 | 400 mcg (0.4 mg) | 12 units (0.12 mL) |
| Weeks 5–8+ | 600 mcg (0.6 mg) | 18 units (0.18 mL) |
- Enhances muscle recovery.
- Reduces inflammation, leading to a significant positive impact on the central nervous system (CNS), muscles, tendons, and damaged tissues.
- Increases muscle hypertrophy and strength.
- Supports tendon-to-bone healing.
- Stimulates collagen synthesis, resulting in anti-aging effects — improves skin condition, diminishes wrinkles, restores thickness to age-thinned skin, and improves elasticity. Promotes hair growth.
- Formation of new blood vessels, improving vasculature, blood flow, and oxygenation of cardiovascular tissues.
- When injected near scar tissue, leads to a reduction in that scar tissue.
- Reduces fat mass.
- Protects against free radical damage to protect the brain and preserve brain function.
- Preserves and improves memory.
- Helps with mood regulation.
- Increases bone density.
- Reduces cartilage lesions and joint pain for improved mobility.
- Interferes with ulcer formation mechanisms; accelerates rebuilding of stomach tissues.
- Elevates dopamine and serotonin levels in the brain, leading to analgesic (pain-relieving) effects.
- Accelerates healing of the colon in those with inflammatory bowel disease.
- Improves tendon, bone, and ligament healing by boosting EGF, FGF, and VEGF levels.
- Normalizes blood pressure in both low and high blood pressure conditions.
- Prevents heart failure caused by potassium imbalance; stabilizes heart rhythm.
- Counteracts life-threatening conditions associated with hypercalcemia.
- Increases production of growth factors that fight infections, strengthening the immune system.
- Has antioxidant properties.
- Helps reverse adverse effects of acute and chronic alcohol intoxication.
- For TBI sufferers, reduces unconsciousness and lowers prevalence of TBI-related deaths.
- For Multiple Sclerosis, decreases brain damage and other clinical abnormalities.
- Counteracts ischemic/reperfusion injuries, improving memory, orientation, and motor function.
- May possess anti-cancer activity by inducing apoptosis of cancer cells.
- Chronic inflammatory conditions
- Arthritis / Osteoarthritis
- Eczema
- Ulcers
- Burn victims
- Achilles tendon injuries
- Muscle crush injuries
- Ligament injuries
- Nerve injuries
- Corneal injuries
- Inflammatory bowel diseases (e.g. Crohn’s)
The gut-brain axis is the direct line of communication between the nervous system and the digestive system. Digestive health impacts neurological health and cognitive function to a substantial degree. BPC-157 can protect the cells lining the gastrointestinal tract; impacts neurotransmitter balance; is being explored for potential treatments for anxiety and depression; reduces symptoms from ulcers, bowel disorders, Crohn’s disease, and other conditions where gut-brain communication is disrupted; and balances the microbial population in the gut.
While side effects are not common, you may experience:
- Nausea
- Diarrhea
- Appetite changes
- Gas/bloating
- Dizziness
- Headaches
- BPC-157 is toxic to fetuses and should not be used when pregnant or nursing.
- Do not take if you have chronic kidney disease.
- Exercise caution with protein allergies, since BPC-157 is a protein.
- If you have an autoimmune disorder, it may be worsened since BPC-157 stimulates the immune system.
- Do not use with active cancer.
- In those with liver or kidney disease, BPC-157 may put additional strain on those organs.
- Exercise caution with heart conditions, as BPC-157 may cause a rise in blood pressure.
Subcutaneous
Pro’s: Provides systemic benefits by entering the bloodstream and circulating throughout the body; good for both general healing and healing multiple injuries.
Con’s: Absorption is slower than IM injections.
Intramuscular
Pro’s: Faster absorption and more noticeable effects. Suitable for acute injuries, post-surgery recovery. Recommended for targeted pain relief near the affected area.
Con’s: Some may consider IM injections to be more difficult and/or more painful.
BPC-157 is often used as a core compound in regenerative peptide stacks. Common research pairings include:
- TB-500 – Synergistic healing of soft tissue, ligaments, and tendons
- Ipamorelin – For stimulating GH release and promoting full-body repair
- CJC No DAC – Enhances GH pulsatility alongside Ipamorelin
- Sermorelin – A GHRH analog to further support repair and recovery
- AOD-9604 – For combining fat reduction with accelerated healing
- GHK-Cu – Known for wound healing and skin repair
- Semax / Selank – Amplify neuroprotective effects and cognitive recovery
PubMed-linked citations for verification. Many studies are animal/in-vitro.
- Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon. J Orthop Res. 2003;21(6):976-82. PMID: 12740856
- Enhancement by BPC 157 of the healing of colonic anastomosis in rats. J Pharmacol Sci. 2007;104(1):7-15. PMID: 17538225
- Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect. J Orthop Surg Res. 2010;5:87. PMID: 20459621
- Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease. Life Sci. 2011;88(11-12):535-42. PMID: 21354401
- Brain-gut axis and pentadecapeptide BPC 157: theoretical and practical implications. Curr Neuropharmacol. 2016;14(8):857-865. PMID: 27031308
- Pentadecapeptide BPC 157 — a therapy for various conditions. J Pharmacol Sci. 2018;138(1):1-8. PMID: 29522634
- BPC 157 effect on healing: early work and gastric protection review. J Physiol Paris. 1999;93(6):501-4. PMID: 10547344
- Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Growth Horm IGF Res. 2014;24(1):22-8. PMID: 19770133
- Therapy with gastric pentadecapeptide BPC 157 for various muscle and tendon pathologies. Eur J Pharmacol. 2005;510(1-2):113-7. PMID: 16024785
- Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics. Neuropsychopharmacology. 2004;29(5):891-8. PMID: 15102861
Research Use Only. All information on this page is for educational purposes only and is not medical advice. PepSherpa does not sell peptides. Consult a licensed healthcare provider before making any health decisions. Many of the studies cited are preclinical (animal/in-vitro).