IMPORTANT: Read the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.
This blend combines two Russian-developed neuropeptides — Selank (10 mg) and Semax (10 mg) — in a single vial. Selank is a synthetic analog of the immunomodulatory peptide tuftsin, studied for anxiolytic (anti-anxiety) activity involving GABAergic and enkephalin pathways. Semax is a synthetic ACTH(4-10) analog studied for nootropic and neuroprotective effects, including modulation of BDNF and support of cognitive function under stress or ischemic conditions. Together the pair is researched for calm, focused cognitive support — Selank addressing the anxiety/stress axis while Semax targets attention, memory, and neuroprotection.
— Selank 10 mg + Semax 10 mg Blend Vial —
Reconstitute: Add 3.0 mL (300 units) bacteriostatic water.
Administration: Subcutaneous injection.
Timing: Dose in the morning and/or early afternoon. Fasting is not required.
Syringes: 0.3 mL (30-unit) or 0.5 mL (50-unit), 30-gauge, 5/16″ tip preferred; 1 mL syringes work but make single-unit measurement harder.
Storage: Refrigerate at 2–8 °C after reconstitution.
Schedule: Daily dosing.
Cycle Length: 4–8 week cycle, followed by a 2–4 week washout period.
Goal: Anxiolytic and nootropic/neuroprotective research support.
Standard Protocol
| Phase | Dose | Syringe (U-100) |
|---|---|---|
| Week 1 | 200 mcg, 1x/day, daily | 3 units (0.03 mL) |
| Week 2 | 300 mcg, 1x/day, daily | 5 units (0.05 mL) |
| Week 3 | 400 mcg, 1x/day, daily | 6 units (0.06 mL) |
| Weeks 4–8 | 500 mcg, 1x/day, daily | 8 units (0.08 mL) |
Maximum Protocol
| Phase | Dose | Syringe (U-100) |
|---|---|---|
| Week 1 | 200 mcg, 2x/day, daily | 3 units (0.03 mL) per dose |
| Week 2 | 300 mcg, 2x/day, daily | 5 units (0.05 mL) per dose |
| Week 3 | 400 mcg, 2x/day, daily | 6 units (0.06 mL) per dose |
| Weeks 4–8 | 500 mcg, 2x/day, daily | 8 units (0.08 mL) per dose |
Note: Keep both daily doses in the morning/early-afternoon window — late-day dosing of stimulatory nootropic peptides can interfere with sleep.
- Anxiolytic (anti-anxiety) activity without sedation (Selank).
- Supports memory, attention, and learning under stress (Semax).
- Studied for neuroprotection in ischemic/hypoxic conditions (Semax).
- Modulation of BDNF and immune/neuro-signaling gene expression.
- May support mood stability via GABAergic and enkephalinergic mechanisms (Selank).
While side effects are not common, you may experience:
- Irritation or redness at the injection site
- Headache
- Fatigue or, conversely, overstimulation/restlessness if dosed late in the day
- Do not use when pregnant or nursing.
- Use caution if taking prescription anxiolytics, sedatives, or psychoactive medication — consult the relevant literature on interactions.
PubMed-linked citations for verification. Many studies are animal/in-vitro.
- Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. Protein Pept Lett. 2018;25(10):914-923. PMID: 30255741
- The role of the opioid system in the anti-anxiety effect of the peptide anxiolytic Selank. Eksp Klin Farmakol. 2012;75(2):10-13. PMID: 22550852
- Functional Connectomic Approach to Studying Selank and Semax Effects. Dokl Biol Sci. 2020;490:9-11. PMID: 32342318
- Synthetic Adrenocorticotropic Peptides Modulate the Expression Pattern of Immune Genes in Rat Brain following the Early Post-Stroke Period. Genes (Basel). 2023;14(7):1382. PMID: 37510287
- Insight into Glyproline Peptides’ Activity through the Modulation of the Inflammatory and Neurosignaling Genetic Response Following Cerebral Ischemia-Reperfusion. Genes (Basel). 2022;13(12):2380. PMID: 36553646
Research Use Only. All information on this page is for educational purposes only and is not medical advice. PepSherpa does not sell peptides. Consult a licensed healthcare provider before making any health decisions. Many of the studies cited are preclinical (animal/in-vitro).