Epithalon

Epithalon (also written Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) associated with the St. Petersburg Institute of Bioregulation and Gerontology and the work of Professor Vladimir Khavinson. It has been studied for effects on aging-related biomarkers, including telomerase activity and telomere dynamics, largely in cell and animal research and select human studies reported by the originating research groups.

Reconstitute: Add 2.0 mL bacteriostatic water → 5 mg/mL concentration.
Typical daily dose: 5,000 mcg (5 mg) once daily for 20 consecutive days.
Easy measuring: At 5 mg/mL, 1 unit = 0.01 mL = 50 mcg on a U-100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C; reconstituted: refrigerate at 2–8 °C, avoid freeze-thaw cycles.

Schedule: Daily subcutaneous injections for 20 consecutive days, followed by 4–6 months off-cycle.
Cycle: 20 consecutive days on, then 4–6 months off. Typically 2 cycles per year.
Goal: Support telomere maintenance, melatonin regulation, and geroprotective effects over time.

Frequency: Inject once daily subcutaneously, preferably in the evening or at bedtime to synergize with natural melatonin rhythms. Complete 20 consecutive days, then observe a 4–6 month off-cycle before repeating (typically 2 cycles per year).

• Telomerase activation and telomere maintenance signals in cell studies (experimental).
• Potential modulation of circadian/sleep-related parameters in aging research contexts.
• Possible immune function changes in aging models.
• General “geroprotective” signaling effects reported by the originating research groups.

• Human safety data is limited and heterogeneous.
• Injection site irritation (if injected).
• Headache or transient fatigue (anecdotal reports).
• Allergic reactions are possible with any peptide.

• Pregnancy/breastfeeding (avoid).
• Active malignancy or high cancer risk: avoid unless under specialist oversight (telomerase-related concerns).
• Immunosuppressive therapy or autoimmune conditions: clinician review recommended.
• Known hypersensitivity.

• Often discussed alongside lifestyle anti-aging pillars (sleep, resistance training, metabolic health).
• If stacking with other “longevity peptides” (e.g., thymic peptides), introduce one variable at a time.

1. Khavinson VKh et al. Biochemistry (Mosc). 2003. PMID: 12680148
2. Anisimov VN et al. Mech Ageing Dev. 2001. PMID: 11596260
3. Khavinson VKh et al. Ontogenez. 2006. PMID: 16913672
4. Khavinson VKh, et al. Bull Exp Biol Med. 2009. PMID: 20126032
5. Korkushko OV et al. Adv Gerontol. 2004. PMID: 15632831
6. Druzhynina NA et al. Bull Exp Biol Med. 2011. PMID: 21436639