Selank

Selank is a synthetic heptapeptide developed in Russia and described as an analog of tuftsin (a natural immunomodulatory peptide fragment of IgG). It has been studied for anxiolytic and nootropic-like effects, with proposed actions involving GABAergic balance, neurotrophic signaling, and immune modulation. In research and anecdotal use, it is commonly administered intranasally; subcutaneous administration is also discussed in peptide communities.

— 5 mg Vial —

Reconstitute: Add 3.0 mL bacteriostatic water → ~1.67 mg/mL concentration.
Typical daily range: 300–500 mcg once daily subcutaneously (gradual titration).
Easy measuring: At 1.67 mg/mL, 1 unit = 0.01 mL ≈ 16.7 mcg on a U-100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C; reconstituted: refrigerate at 2–8 °C, avoid freeze-thaw cycles.

Schedule: Daily subcutaneous injections for 4-week cycles with 4-week breaks.
Cycle: 4 weeks on, 4 weeks off to prevent tachyphylaxis.
Goal: Support reduction of anxiety and neurasthenia symptoms while providing anti-asthenic (energy-boosting) benefits.

Frequency: Inject once daily subcutaneously. Some practitioners recommend administering 5 days per week with 2-day breaks.

— 10 mg Vial —

Reconstitute: Add 3.0 mL bacteriostatic water → ~3.33 mg/mL concentration.
Typical daily range: 300–500 mcg once daily subcutaneously (gradual titration).
Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U-100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C; reconstituted: refrigerate at 2–8 °C, avoid freeze-thaw cycles.

Schedule: Daily subcutaneous injections for 4-week cycles with 4-week breaks.
Cycle: 4 weeks on, 4 weeks off to prevent tachyphylaxis.
Goal: Support reduction of anxiety and neurasthenia symptoms while providing anti-asthenic (energy-boosting) benefits.

Frequency: Inject once daily subcutaneously. Some practitioners recommend administering 5 days per week with 2-day breaks.

• Anxiolytic-like effects in clinical/research reports (notably Russian literature).
• Possible cognitive support under stress (memory/attention measures in some studies).
• Potential modulation of inflammatory/immune markers (tuftsin-analog rationale).
• May influence expression of certain neurotrophic factors in experimental models.

• Nasal irritation (intranasal use).
• Headache (occasionally reported).
• Transient fatigue or agitation (individual variability).
• Allergic-type reactions are possible with any peptide (rare; discontinue and seek care).

• Pregnancy/breastfeeding (avoid; insufficient safety data).
• Severe psychiatric illness without clinician oversight.
• Known hypersensitivity to peptide components/excipients.
• Autoimmune disease or immunomodulator use: discuss with a clinician.

• Often discussed alongside Semax for “daytime focus + calm” protocols; start one at a time to assess tolerance.
• May be paired with sleep/stress interventions (CBT, breathwork, magnesium) as foundational support.

1. Ashmarin IP, Nezavibatko VN, et al. Neurosci Behav Physiol. 2003. PMID: 12680677
2. Kozlovskii II et al. Neurosci Behav Physiol. 2008. PMID: 18320176
3. Morozov SG, et al. Bull Exp Biol Med. 2003. PMID: 14731267
4. Andreeva LA et al. Bull Exp Biol Med. 2006. PMID: 17172861
5. Gudasheva TA, et al. Neurosci Behav Physiol. 2008. PMID: 18991527
6. Kost NV, et al. Bull Exp Biol Med. 2009. PMID: 20108520